Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.537


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.766.3e-04Click!
SOX2chr3_+_1829124050.312.4e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_95794416 2.287 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_+_114033403 1.750 NM_058222
TECTB
tectorin beta
chr4_+_77575276 1.741 NM_020859
SHROOM3
shroom family member 3
chr18_-_56190980 1.706 NM_005912
MC4R
melanocortin 4 receptor
chr7_+_89681069 1.635 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr10_-_73518772 1.607 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr10_+_77212524 1.564 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr12_-_10846435 1.495 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr12_-_66839589 1.488 NM_000619
IFNG
interferon, gamma
chr1_-_150328153 1.479 NM_001008536
TCHHL1
trichohyalin-like 1
chr7_+_29486010 1.471 NM_001039936
CHN2
chimerin (chimaerin) 2
chr3_-_156904690 1.419 NM_014996
PLCH1
phospholipase C, eta 1
chr4_+_185063421 1.293 NM_020225
STOX2
storkhead box 2
chr3_-_42280442 1.289 NM_001174138
CCK
cholecystokinin
chr9_-_4142182 1.286 NM_152629
GLIS3
GLIS family zinc finger 3
chr2_+_204509698 1.191 NM_012092
ICOS
inducible T-cell co-stimulator
chr13_-_27441290 1.177 NM_001265
CDX2
caudal type homeobox 2
chr1_-_155936904 1.169 NM_052939
FCRL3
Fc receptor-like 3
chr17_-_25685175 1.129 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr3_+_157491469 1.124 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_57811645 1.092 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr4_+_114433551 1.084 ANK2
ankyrin 2, neuronal
chr12_+_7755316 1.056 NM_199286
DPPA3
STELLAR
developmental pluripotency associated 3
developmental pluripotency associated 3 pseudogene
chr1_+_156842852 1.050 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr9_-_21177529 1.047 NM_021068
IFNA4
interferon, alpha 4
chr2_-_238813365 1.030 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr13_-_27441143 1.030 CDX2
caudal type homeobox 2
chr9_+_21399132 1.027 NM_002170
IFNA8
interferon, alpha 8
chr10_+_91127792 1.018 NM_001010987
IFIT1B
interferon-induced protein with tetratricopeptide repeats 1B
chr6_-_101018271 1.006 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr5_+_79366746 0.995 NM_003248
THBS4
thrombospondin 4
chr9_-_21340885 0.972 NM_021002
IFNA6
interferon, alpha 6
chr3_+_45902999 0.958 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr11_+_123945102 0.957 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr7_+_142629251 0.955 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr11_-_117552545 0.955 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr12_+_7833261 0.921 NM_024865
NANOG
Nanog homeobox
chr13_-_27441423 0.911 CDX2
caudal type homeobox 2
chr5_+_140751666 0.910 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr2_-_238813284 0.900 HES6
hairy and enhancer of split 6 (Drosophila)
chr15_-_76313896 0.899 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr9_+_134843918 0.892 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr9_-_21229975 0.875 NM_002172
IFNA14
interferon, alpha 14
chr9_-_21197141 0.861 NM_002171
IFNA10
interferon, alpha 10
chr10_-_74863303 0.823 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr13_+_108079570 0.821 NM_001198950
MYO16
myosin XVI
chr12_-_7547552 0.820 NM_004244
NM_203416
CD163

CD163 molecule

chr3_+_99484421 0.819 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr18_-_59462469 0.814 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chrX_+_135106578 0.809 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr12_+_7833292 0.774 NANOG
Nanog homeobox
chr3_+_63403792 0.764 NM_144642
SYNPR
synaptoporin
chr12_+_20854904 0.759 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr12_+_103221590 0.755 NM_001008394
EID3
EP300 interacting inhibitor of differentiation 3
chr18_+_50646616 0.753 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr1_-_146492471 0.751 NM_015383
NBPF14
NBPF1
neuroblastoma breakpoint family, member 14
neuroblastoma breakpoint family, member 1
chr4_-_21155376 0.750 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr12_-_9123126 0.747 A2M
alpha-2-macroglobulin
chrX_+_135397790 0.744 NM_001727
BRS3
bombesin-like receptor 3
chr7_+_37689903 0.730


chr10_-_69125932 0.721 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr18_-_26876622 0.719 NM_001941
NM_024423
DSC3

desmocollin 3

chr13_+_96592051 0.717 MBNL2
muscleblind-like 2 (Drosophila)
chr9_-_21192201 0.713 NM_021057
IFNA7
interferon, alpha 7
chr10_+_124141808 0.712 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chrX_+_7147471 0.700 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr2_-_171631728 0.693 NM_001136555
TLK1
tousled-like kinase 1
chr4_-_123761615 0.691 NM_021803
IL21
interleukin 21
chr8_-_93099040 0.684 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_+_140719773 0.676 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr4_+_154397975 0.672 TRIM2
tripartite motif containing 2
chr12_-_69600514 0.663 PTPRR
protein tyrosine phosphatase, receptor type, R
chr4_-_41445479 0.661 PHOX2B
paired-like homeobox 2b
chr3_-_56784634 0.658 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr11_-_128242342 0.648 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr16_+_70646008 0.639 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_190552744 0.637 NM_001039152
RGS21
regulator of G-protein signaling 21
chr6_-_76838944 0.635 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr6_+_50894397 0.635 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr9_+_6205804 0.633 IL33
interleukin 33
chr13_+_22653059 0.623 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr3_+_109504021 0.621 NM_007072
HHLA2
HERV-H LTR-associating 2
chr8_-_26780645 0.617


chr12_+_102859354 0.614 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_+_116181927 0.612 NHLH2
nescient helix loop helix 2
chr5_-_135318420 0.601 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr2_-_215998181 0.601 FN1
fibronectin 1
chrX_-_55037235 0.600 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_-_107230867 0.595 NM_000111
SLC26A3
solute carrier family 26, member 3
chr16_+_74868676 0.594 NM_033401
CNTNAP4
contactin associated protein-like 4
chr1_-_93172119 0.591


chr4_+_14950657 0.586 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr3_+_99555387 0.584 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chrX_-_15312390 0.581 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr10_+_123744131 0.575 TACC2
transforming, acidic coiled-coil containing protein 2
chrX_+_135210787 0.572 NM_153834
GPR112
G protein-coupled receptor 112
chr16_+_52081836 0.571 RBL2
retinoblastoma-like 2 (p130)
chr3_-_38810504 0.570 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr3_+_12367993 0.567 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr7_+_129057152 0.565 NM_001040110
NRF1
nuclear respiratory factor 1
chr2_-_215949566 0.562 FN1
fibronectin 1
chr3_+_149930656 0.558 NM_032049
AGTR1
angiotensin II receptor, type 1
chr11_-_117552355 0.557 SCN2B
sodium channel, voltage-gated, type II, beta
chr12_-_88573949 0.554 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr1_-_108588186 0.553 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chrX_+_70255128 0.551 NM_005120
MED12
mediator complex subunit 12
chr9_-_21156609 0.544 NM_002175
IFNA21
interferon, alpha 21
chr3_-_42892195 0.541 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_+_29606408 0.539 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr11_+_113280727 0.537 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr14_-_20098929 0.536 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr14_+_61532293 0.529 NM_031914
SYT16
synaptotagmin XVI
chr2_-_37397669 0.528 NM_005813
PRKD3
protein kinase D3
chr8_-_26780665 0.526 ADRA1A
adrenergic, alpha-1A-, receptor
chr1_-_3556420 0.516 NM_017818
WDR8
WD repeat domain 8
chr10_-_52315436 0.514 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr5_+_140762551 0.510 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr2_-_20390601 0.508 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr14_-_106149623 0.503


chr1_-_229071957 0.498 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr1_+_86785346 0.491 NM_012128
CLCA4
chloride channel accessory 4
chr11_-_57171554 0.491 YPEL4
yippee-like 4 (Drosophila)
chr3_+_99370233 0.487 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr2_-_200038055 0.486 NM_001172517
SATB2
SATB homeobox 2
chr12_+_54231249 0.485 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr4_+_74493918 0.485 ALB
albumin
chr1_-_41398126 0.484 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr6_-_32605898 0.482 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr1_-_175400441 0.474 ASTN1
astrotactin 1
chr15_+_19883745 0.474 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr4_-_41445693 0.473 NM_003924
PHOX2B
paired-like homeobox 2b
chr9_+_91409746 0.470 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr4_-_165338312 0.469 NM_012403
ANP32C
acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
chr6_-_89984214 0.468 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr12_+_54172413 0.466 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr12_-_100128115 0.462 NM_145913
SLC5A8
solute carrier family 5 (iodide transporter), member 8
chrX_+_141941369 0.455 NM_001009613
SPANXN4
SPANX family, member N4
chr8_+_7340777 0.451 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr15_+_63701322 0.447 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr4_-_74307637 0.446 ANKRD17
ankyrin repeat domain 17
chr3_+_99350859 0.446 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chrX_-_138875342 0.443 NM_001013403
CXorf66
chromosome X open reading frame 66
chr4_+_120276386 0.439 NM_016599
MYOZ2
myozenin 2
chr2_-_45648608 0.437 SRBD1
S1 RNA binding domain 1
chr8_+_142501188 0.437 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr8_-_7297296 0.434 NM_058206
NM_058207
SPAG11B

sperm associated antigen 11B

chr12_-_21379098 0.434 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr1_-_175400573 0.430 NM_004319
NM_207108
ASTN1

astrotactin 1

chr10_+_124660206 0.430 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr7_-_122126422 0.430 NM_139175
RNF133
ring finger protein 133
chr3_-_174341653 0.424 NM_031955
SPATA16
spermatogenesis associated 16
chr10_-_5436781 0.423 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr11_-_102100833 0.423 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr2_+_89715037 0.420


chr3_-_110155237 0.416 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr12_+_54106304 0.413 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr9_-_21132143 0.413 NM_002177
IFNW1
interferon, omega 1
chr2_-_165768798 0.413 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr3_+_2908920 0.412 NM_175613
CNTN4
contactin 4
chr12_+_47162552 0.410 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr10_-_7699192 0.409 ITIH5
inter-alpha (globulin) inhibitor H5
chr11_-_57927457 0.406 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr11_-_35398077 0.405 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_-_59480082 0.400 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr4_-_149577404 0.400


chr8_+_120148604 0.399 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr7_-_16811131 0.392 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr11_-_58368555 0.391 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr6_-_22410993 0.387 NM_001163558
PRL
prolactin
chr1_+_93072947 0.387 RPL5
ribosomal protein L5
chr15_+_36014748 0.386 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr11_+_59804634 0.383 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr4_-_151993422 0.381


chr1_-_161380562 0.381 RGS5
regulator of G-protein signaling 5
chr13_+_112746908 0.380 MCF2L
MCF.2 cell line derived transforming sequence-like
chr18_+_41448763 0.379 NM_007163
SLC14A2
solute carrier family 14 (urea transporter), member 2
chr1_-_157772420 0.377 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr5_-_58331515 0.377 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_55489973 0.376 WNT5A
wingless-type MMTV integration site family, member 5A
chr10_+_90552466 0.376 NM_001128215
LIPM
lipase, family member M
chr14_-_57030227 0.374 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr3_+_191588354 0.374 NM_006580
CLDN16
claudin 16
chr6_-_119512035 0.373 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr7_+_45899621 0.372


chrX_+_54483565 0.371 NM_058163
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr11_-_19038803 0.368 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr22_+_34025267 0.368 NM_001135729
TOM1
target of myb1 (chicken)
chr13_-_43101608 0.365 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr11_-_59390518 0.364 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr10_+_95838801 0.361 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr4_+_88939725 0.359 NM_004967
IBSP
integrin-binding sialoprotein
chr12_+_129212955 0.357 NM_007197
FZD10
frizzled homolog 10 (Drosophila)
chr18_+_61568825 0.355 CDH7
cadherin 7, type 2
chrX_+_10084984 0.352 NM_001830
CLCN4
chloride channel 4
chr9_-_111230926 0.352 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_-_116185215 0.351 NM_005599
NHLH2
nescient helix loop helix 2
chr7_-_122422989 0.350 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr15_-_39151468 0.347 INO80
INO80 homolog (S. cerevisiae)
chr7_-_100092003 0.343 NM_016188
ACTL6B
actin-like 6B
chr4_-_154929657 0.339 NM_003013
SFRP2
secreted frizzled-related protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.92 8.03e-10 GO:0007606 sensory perception of chemical stimulus
2.28 1.88e-08 GO:0007600 sensory perception
2.80 1.84e-07 GO:0007608 sensory perception of smell
1.36 1.46e-06 GO:0032501 multicellular organismal process
1.84 2.54e-06 GO:0050877 neurological system process
1.69 1.53e-05 GO:0003008 system process
1.27 1.31e-04 GO:0050896 response to stimulus
6.84 6.69e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
9.39 7.57e-03 GO:0032660 regulation of interleukin-17 production
1.79 4.54e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 9.20e-09 GO:0005886 plasma membrane
1.44 1.41e-08 GO:0071944 cell periphery
1.65 1.67e-07 GO:0005576 extracellular region
1.92 1.97e-06 GO:0044421 extracellular region part
1.94 6.47e-05 GO:0005615 extracellular space
1.38 1.98e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.10 1.34e-11 GO:0004888 transmembrane receptor activity
2.38 6.60e-11 GO:0004930 G-protein coupled receptor activity
1.75 8.01e-10 GO:0004871 signal transducer activity
1.75 8.01e-10 GO:0060089 molecular transducer activity
1.84 1.52e-09 GO:0004872 receptor activity
2.93 7.36e-09 GO:0004984 olfactory receptor activity
3.63 1.07e-02 GO:0004867 serine-type endopeptidase inhibitor activity