Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.537


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.766.3e-04Click!
SOX2chr3_+_1829124050.312.4e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_95794416 2.287 NM_000439
 PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_+_114033403 1.750 NM_058222
 TECTB
tectorin beta
chr4_+_77575276 1.741 NM_020859
 SHROOM3
shroom family member 3
chr18_-_56190980 1.706 NM_005912
 MC4R
melanocortin 4 receptor
chr7_+_89681069 1.635 NM_001040666
 STEAP2
six transmembrane epithelial antigen of the prostate 2
chr10_-_73518772 1.607 NM_001134434
NM_014767
 SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr10_+_77212524 1.564 NM_032024
 C10orf11
chromosome 10 open reading frame 11
chr12_-_10846435 1.495 NM_023919
 TAS2R7
taste receptor, type 2, member 7
chr12_-_66839589 1.488 NM_000619
 IFNG
interferon, gamma
chr1_-_150328153 1.479 NM_001008536
 TCHHL1
trichohyalin-like 1
chr7_+_29486010 1.471 NM_001039936
 CHN2
chimerin (chimaerin) 2
chr3_-_156904690 1.419 NM_014996
 PLCH1
phospholipase C, eta 1
chr4_+_185063421 1.293 NM_020225
 STOX2
storkhead box 2
chr3_-_42280442 1.289 NM_001174138
 CCK
cholecystokinin
chr9_-_4142182 1.286 NM_152629
 GLIS3
GLIS family zinc finger 3
chr2_+_204509698 1.191 NM_012092
 ICOS
inducible T-cell co-stimulator
chr13_-_27441290 1.177 NM_001265
 CDX2
caudal type homeobox 2
chr1_-_155936904 1.169 NM_052939
 FCRL3
Fc receptor-like 3
chr17_-_25685175 1.129 NM_206832
 TMIGD1
transmembrane and immunoglobulin domain containing 1
chr3_+_157491469 1.124 NM_172159
 KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
9.39 7.57e-03 GO:0032660 regulation of interleukin-17 production
6.84 6.69e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
2.92 8.03e-10 GO:0007606 sensory perception of chemical stimulus
2.80 1.84e-07 GO:0007608 sensory perception of smell
2.28 1.88e-08 GO:0007600 sensory perception
1.84 2.54e-06 GO:0050877 neurological system process
1.79 4.54e-02 GO:0006955 immune response
1.69 1.53e-05 GO:0003008 system process
1.36 1.46e-06 GO:0032501 multicellular organismal process
1.27 1.31e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.94 6.47e-05 GO:0005615 extracellular space
1.92 1.97e-06 GO:0044421 extracellular region part
1.65 1.67e-07 GO:0005576 extracellular region
1.45 9.20e-09 GO:0005886 plasma membrane
1.44 1.41e-08 GO:0071944 cell periphery
1.38 1.98e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.63 1.07e-02 GO:0004867 serine-type endopeptidase inhibitor activity
2.93 7.36e-09 GO:0004984 olfactory receptor activity
2.38 6.60e-11 GO:0004930 G-protein coupled receptor activity
2.10 1.34e-11 GO:0004888 transmembrane receptor activity
1.84 1.52e-09 GO:0004872 receptor activity
1.75 8.01e-10 GO:0004871 signal transducer activity
1.75 8.01e-10 GO:0060089 molecular transducer activity